Thanks for the replies, guys. TC Electronic does indeed make an audio interface, The Desktop Konnekt 6. Which is a firewire audio interface and monitor control. Check it out here:

http://www.tcelectronic.com/desktop-konnekt-6/

I've had this unit for about six years and it works just fine. I'm running it on a custom built Intel box with a quad-core Intel processor and 8 gigs of ram. OS is MS Vista Ultimate.

The problem seems to be more with BIAB than with the interface which I also use with REAPER with no problems. It could be song specific as I've noticed it sometimes when opening a demo song into the BIAB chord window. Could be a buffer thing. I will experiment with BIAB preferences, settings, to see if that makes a difference.

Noel suggested using the MME Windows driver instead of the ASIO and see if it makes a difference. I've had the TCH interface a lot longer than I've had the new version of BIAB and it's worked well. So I'm thinking it's some setting in BIAB. Strange no one else has seen this, but all of our systems are different. So as a computer friend of mine likes to say "it could be a million things." LOL Not too comforting, but true.

I'll report on here when I find the culprit. And I WILL find it. The TCH setup I have is only one of six we have here, most with custom computers that I built, so I'm a total geek. We run separate systems for Cubase, Sonar Producer, ProTools, and Reaper. I'll find it or die trying. Haha.

Thanks again,
Rob