I don't really know which one I'd choose since I haven't shopped around recently. Currently using Berhinger UMC204HD interface. It probably wouldn't be my first choice if budget was not such a concern. However, I do get a really nice recorded sound and playback with it. Especially compared to when I was using a mixer connected directly to the computer sound card via 1/8 stereo input. The UMC204HD touts "Midas" preamps. I'm in no delusion that they are the exact preamps used on their highest quality consoles though. But, who knows? I do think the room and the mic have a whole lot to do with it also.

Yes, I agree, the Yamaha MG mixers have very decent mic preamps and a nice circuit all the way through to each output.

The reason I would not get a USB version of any current small foot print mixer is because I think/assume it would be limited compared to the current set up I have. The little USB boards I've seen don't have all/as many routing/assigning abilities as my dated MG124CX. (Not MG12CSX as stated earlier.)
And, I'm assuming there is some type of quality difference between a bare-bone 2 channel interface for $150 - $250 and a full function 2 channel USB mixer for around the same price. Did they cut corners somewhere? But, I admit, I am making assumptions and have not recently done any comparisons. I certainly wouldn't want to lose the functionality I'm currently getting in a multi-task situation.
I did use a borrowed Focusrite 2i2 interface (1st generation) for a little while and I like the Behringer UMC204HD more. I think it sounds better, takes a hotter/louder input signal before distorting, has 6 outputs plus a louder headphone playback, and a few more buttons to poke at on the front. But, I'm not claiming to be the interface expert here.

Does the noise in your head bother me ?