No problems here running Mac's Band 2017 ( Audiophile as well as non Audiophile USB's ) in macOS Sierra 10.12.5 .

Therefore I am rather surprised to read about your problems.

However with each Mac OS upgrade my available RAM keeps shrinking which is always the case in my 30+ years of working/using ( playing ) with the Mac going as far back as OS 7.5 and Mac Band version 5 ( those floppy disk days ).

Cubase, Digital Performer, Sibelius, Finale and my many other music programmes all work well with macOS Sierra 10.12.5 . Yes, I am a computer music junkie.