Yes, this has happened to me in the past.

Using the transport control to go to the end of the song can reveal over a thousand apparently empty bars and if the song is saved in this state, it won't open again, displaying a message that the file is too large.

I find the easiest way to delete the extra bars is from the BARS window. It's a simple task to highlight lots of bars over all the tracks.

Exactly why this happens is not clear, as John said, but it's only happened to me twice and not for a long time now.

ROG.