Quote:
.. I can imagine that problems could arise using multiple drives ..


Personally I think using multiple drives is beneficial .. but I wouldn't record (write) to a USB drive. Too much bandwidth needed especially if multi-tracking. 'Reading' Realtracks and Realdrums from the external USB works fine, but writing is a different story.

RB/PT lets you select your Temp Audio Directory. This is where incoming (recorded) data gets temporarily written to. Once you save the file (not 'keep take', but actually save the file) it gets saved to the drive that holds the file, but during a working session this Temp Audio Directory can get a lot of use.
I use a separate internal hard drive for the Temp Audio Directory.

That said, I use another separate internal hard drive to read the RT/RD's.
My drive layout is shown below.
The BB_RB drive holds my current RT/RDs. (kept up to date)
The audio_SysBackup drive holds my Temp Audio Directory
BiaB, RB and PT all run from C:

The other drives are system backups and general storage
I keep the PGMusic external drives as separate backups (not connected) so they don't show in the image below.

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I do not work here, but the benefits are still awesome
Make your sound your own!