Unfortunately, re-boot does not clear the "hold" on the device. Nor does a power cycle of the MOTU Audio Express.

Nor does RTFS in BIAB which tries to reset to WAS, but can't because of the Hold.

Interesting that REAPER does not have any problem. So whatever is holding it, does not impact Reaper, but Reaper does not clear the hold when it exits. Maybe a clue there?

BIAB, YouTube and all other system audio remains silent.

All looks good in the Win10 Sounds Setup page. But the "test" throws and error when I press it.

Whatever is doing this, it is new as of the past several weeks.

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I deleted my Drivers, Rebooted, Reinstalled the Drivers.... and all is back to normal.

BIAB – 2025, Reaper (current), i7-12700F Processor, 32GB DDR4-3200MHz RAM, 1TB WD Black NVMe SSD, 2TB WDC Blue SSD, 1TB WD Blue, 2 TB SK NVMe, 6 TB External, Motu Audio Express 6x6