When I’m playing piano using midi, I still find ASIO with jBridge to work best.....although I sure wish Windows would develop something like Core Audio/midi to take the guesswork out of the equation. The lowest latency I’ve ever seen is 3ms round trip using RME interfaces, even Thunderbolt interfaces don’t do that well....USB2 provides plenty of bandwidth, but if you’re using a garden variety consumer interface (Roland/M Audio Focusrite, etc) you won’t get great performance.....I’ve had them all, even apogee, and RME is just stellar.....