Originally Posted By: Matt Finley

Is this an older M-Audio 2496 card? Running on ASIO? Increase the buffer size.

I increased the buffer size and it solved the problem. It was 64, went to 256 and problem gone. Tried 128 and it was better than 64 but still noticeable. I have no idea what caused this to show up, but I'm happy it's solved.
tnx