I'll try this again.
The graphic shown by Fiddletr2007, and the article posted by Kent, refer to power settings. There are the obvious ones for CPU percentage at minimum 100%, and not turning off the monitor or hard drive after a set time.
But the one fewer people seem to know about that can really fool you is the USB Settings, USB Selective Suspend. This should be set to DISABLE.
A similar one is PCI Express, Link State Power Management. That should be set to OFF.
In general, don't let Microsoft do any 'management' of your power.
And check these settings after each operating system update. They can get flipped.
Matt,
I'll try changing these two Power Management settings on the laptop as you suggested, and see what happens. Inasmuch as I am not getting the audio stutter problem on my Windows 10 (R3) desktop system with Build 512 using the internal Realtek audio hardware on the internal CPU bus, I'm thinking that there might still be a problem with the laptop-to-UR22MKii interface via the USB port. Steinberg did release a Firmware update in December to "fix" a data loss problem when a lot of MIDI data is being transmitted. Even though I have installed this update, maybe there is still a problem with their USB link.