Win10 updates have been killing my MOTU drivers for as long as I can remember. I have discovered an easy fix. When my audio stops I simply go into "programs - add / remove". Select the MOTU Audio, then "repair". After a quick reboot all is well again.

YMMV.


BIAB – 2025, Reaper (current), i7-12700F Processor, 32GB DDR4-3200MHz RAM, Motu Audio Express 6x6 - My SoundCloud (Tip: No need to create a SC account to hear music - just hit ESC ).