Maybe so, but if all is stored on one larger (SATA) drive, one GPT partition, you'll need more time for defragmenting.

Also i like an overview of what's where, and the ability of backing up large data chunks in one flow especially from collected samples, projects, you name it, in an organized way. f.i. i got a 2TB SATA drive with only PGstuff, almost full now, a 3TB containing all the collected VST sounds for stuff like Kontakt, Toontrack. Another drive with stocked collected video footage for youtubing clips. And then a small SSD with the boot stuff, and a slightly larger one with programs i regularly use.

Besides, if one drive prove to be less reliable, just pull it out and replace it with far less copying work afterwards. The only way out of the ever-growing data storage capacities needed, is some kind of external cloud, or a totally different compression method. And programmers who program their stuff in a more efficient way ...... F