Not much to go on here. However, maybe I have a similar problem at times and maybe my fix might help.

I have traced the problem to my sound card getting messed up (that is a technical term). I blame in on Windows 10 updates or god knows what, but the audio just goes silent. My fix, reset my sound card drivers. I open Programs and select "motu hardware". then I click on it and select "fix". Following a reboot, It always works.

YMMV


BIAB – 2025, Reaper (current), i7-12700F Processor, 32GB DDR4-3200MHz RAM, 1TB WD Black NVMe SSD, 2TB WDC Blue SSD, 1TB WD Blue, 2 TB SK NVMe, 6 TB External, Motu Audio Express 6x6