Mike,
Depending on how many targets you have, a S&W revolver, in the right caliber, will do as much, or more damage, than a Glock, especially in 9mm. Personally, I like .357 Magnum. However, my choice is my reliable 1911A1 .45. If you're in a situation where you need to reload, and you're inside your house, you're already dead.
Gary