Robh, what version of Reaper are you running - don't think anyone has mentioned? Are you disabling your antivirus or white listing the BIAB executable?
It may just be something simple in your configurations.
PGM needs to provide a diagnostic file which records errors which we can send to them to troubleshoot!
BIAB – 2025, Reaper (current), i7-12700F Processor, 32GB DDR4-3200MHz RAM, 1TB WD Black NVMe SSD, 2TB WDC Blue SSD, 1TB WD Blue, 2 TB SK NVMe, 6 TB External, Motu Audio Express 6x6
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