The short answer is yes. You would load a midi file (which goes to the melody track) and press Shift-F5 (or use the Reharmonist button).

However, you would probably need to remove most of the midi tracks such as bass and drums. Basically you want to go to Edit|Copy/Move Tracks and move, or delete, all the tracks except your melody. Then the ReHarmonist can do it job properly.

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