Matt,
Looks like this thread went dead, so I hope you don't mind if I jump in here with a similar question.

I see what you're saying about bit rate and depth for BIAB ---- 44.1Khz and 16-bit.
I'm using ASIO with an Audient id14 USB interface, and every program I use is set to 24-bit 48Khz, and that's my default setting.
But, when I run BIAB, 32 or 64, the settings automatically change and lock in at 44.1Khz. When I go back to Reaper, for example, it reverts back to 48Khz. All of this was setup a couple years ago for video editing (my cell phone defaults to 48Khz) and I just ran with that in Reaper projects.

But now I see what happens with BIAB. It's rather weird....... BIAB forces the Audient interface to 44.K, but my Windows settings still stay at 48K! Problem is, do I reset all my default settings to 44.1Khz now. I'm concerned that previously recorded stuff at 48K will have sync issues, speed up, etc. Also, I noticed some songs had audio at 48K, some had 44.K --- and if they're mixed in on a MIDI song, things get out of sync real quick.

What would be the best way to proceed for me? Does BIAB or RealBand somehow compensate the audio of differing rates? Thanks for any advice.

Jerry
2019 BiaB Megapack (634), RB 2019 (Build 4)
Reaper 5.983 x64, Audient id14 USB interface, Voicemeeter Potato 3.0.0.8, Nektar LX49+, Roland E20
i7-6700K Skylake desktop, 64bit Win10 Pro(1903), 32GB ram, 512GB system SSD + 2TB data SSD