Reaper is good and inexpensive (something like $69). Cakewalk by BandLab (which is what used to be the somewhat pricey Sonar Platinum) is free, so at least worth checking out. Acoustica Mixcraft is nice also and not too expensive.
I could never really wrap my head around Cubase or Tracktion (now called Waveform), both of which I have, but that could just be me. Likewise for N-Track. And Multitrack Studio works, but is more basic and I don't care for its more sparse interface.
Just my $0.02 worth, and losing value every day.

EDIT: I generally use either Realband or Cakewalk by BandLab. The Sonar interface for me was more comfortable than the others. But as has already been said, to each his own.