Drivers are the only problem I've heard about also, but that's certainly a serious problem if you don't have a good one for a device you wish to use in 64-bit. My Tascam control surface, for example, does not fully function in 64-bit, according to other users who have tried, and will cause a BSOD if you don't turn it off before shutting down Windows. Before the current driver that has these problems, the previous driver caused clicks and pops if you used more than 3 GB of RAM, which is of course one of the main reasons why one would want to use a 64-bit OS, and users had to remove all but 2 GB of their RAM. This kind of annoyance does not exist with their 32-bit drivers for the same equipment.

The situation has recently changed a lot, though, for the better (except for Tascam).

BIAB 2025 Win Audiophile. Software: Studio One 7 Pro, Swam horns, Acoustica-7, Notion 6, Song Master Pro, Win 11 Home. Hardware: Intel i9, 32 Gb; Roland Integra-7, Presonus 192 & Faderport 8, Royer 121, Adam Sub8 & Neumann 120 monitors.