MIDI is so low in the usage of computer resources that I don't think you will solve it by looking at your audio software or settings. Instead, as this is a different computer, I recommend ruling out malware first. Malwarebytes and Super Anti Spyware are good starts.

You might also look for bloatware that is hogging the resources, especially if you hear skips playing back audio (not MIDI). The free DPC Latency Checker will find that quickly. It says it isn't for Windows 10 but it works fine; just consider 1000 the new zero.

BIAB 2025 Win Audiophile. Software: Studio One 7 Pro, Swam horns, Acoustica-7, Notion 6, Song Master Pro, Win 11 Home. Hardware: Intel i9, 32 Gb; Roland Integra-7, Presonus 192 & Faderport 8, Royer 121, Adam Sub8 & Neumann 120 monitors.