Prado.
ok..so rme.
a very fine sound device as i'm sure your aware. and no i'm not assuming your
a noob to digital audio.
by the by as i'm sure your aware asio introduces its own overhead.
(by the way ive used asio at length as well as other non asio formats like wdm etc)
so your saying your rme dont play nice with biab ..correct ??
nor your layla (another good device) correct ??
mebe it is a biab issue..but follow my weird mind..
cos i like to try n trak things down.

both those devices have user control panels..correct ??
what ive seen sometimes with these user control panels ..
and an important point to note is..sometimes the way a user
control panel is set up in one daw music software might need a different setting
in another daw software.

lets be constructive bout this.
post pics of each user control panel that you know works well in other daw software.
just amuse me please..theres method in my madness..lol.

i would like to make one important point also mate.
the way pc architecture works is the music software daw or application..
is seperated from the sound device.
win sits in the middle of everything running tasks n processes
rather like a traffic cop.
all the music app does at start up is ask win whats installed on the users
machine and win reports back.
(for more info peruse the MS developers site called MSDN and look up enumeration
of devices.)
in summary the music app itself could be accessing the freddy splunge
sound device. all the music app knows is what win tells it is installed
re sound devices. then the user chooses in the music app the
I/O//drivers to be used.
the reason i'm stateing the above is some users assume that there is a close
direct relationship tween the music app and the sound device.
but in fact its more of an arms length relationship if you peruse
the MSDN site and delve into the midi and audio api's that developers of
midi and audio software use when developing in win.

so what fazes users is why does my xyz sound device work well with
one piece of daw software but not another. ??
or why does xyz sound device work on my mates puter but not mine ??
youll see these questions on many forums.
even why does asio work on one of my pc's but not the other ??
seen that one too.

my answer is there are many variables that need to be considered.
mebe it is biab's asio implementation..but it might not be.
obviously some folks here are useing asio ok.
there are other variables. mebe for example its a setting in a sound devices user control panel.
ive seen many times where a user is swearing blind its the daw software..
(sonar//samp//saw//audition//any other daw software you can name)
only to find out it was a setting in the user control panel.
(or sometimes incorrect driver assignment)
assuming the correct I/O drivers have been assigned in the daw software.
which is why i'm asking you to show pics of your user control panel
settings for your sound devices. it might be a blind end..but might not.

retired puter engr....powertracks on amd......NICE !
"what is the black art of audio engineering ?"
my silly songs...motagator.com/bmanning
see my tips in the tips section.