If you get an error like that (an access violation that is), then program likely wouldn't function properly afterwards and should be restarted.

(1) Try selecting a 'Default synth' / make sure that 'none' is not selected... You can do this via Options | driver setup | VSTi/DXi synth. e.g. select Coyote Wavetable.

(2) As an experiment, does the program boot up without the error message if you add a file called safemode.txt to the Preferences folder (just a test, you should delete the file after).

(3) If possible, please attach a text file with the error report to your reply, using the File Manager.

Andrew
PG Music Inc.