Keith, we have been talking about MIDI and not audio. What are your Edirol UM1X settings? What OS are you using? Is there a possibility that a Win 10 update messed with the Edirol drivers? If you have the original drivers, or you can get them, it might be wise to install them.

If you are using Win 10 it is possible that the unit is not compatible with it. You stated that it works fine with just MIDI but when you mix MIDI with audio you get problems. A bit rate mismatch can cause those types of problems.

I say the Edirol might not be compatible with Win 10 because the docs say it was for Win 98/XP. I do not know if there has been driver updates so it is compatible with Win 10 so you may want to investigate that.

Don't give up. I have had some weird issues with the latest 2021 also.

Whenever I get something stuck in the back of my throat, I dislodge it by drinking a beer.
It's called the Heineken Maneuver.

64 bit Win 10 Pro, the latest BiaB/RB, Roland Octa-Capture audio interface, a ton of software/hardware