Most, not all, C trumpets play more in tune with 1 & 3 for D above middle C, then 2 & 3 for Eb, then 1 & 2 for E. Doesn't matter much what key you are in; if the note is flatter than a pancake, it's going to sound bad in any key. For most players, I think lipping up is harder than lipping down.

I never use 3 alone on a C. I use 3 alone a lot on a Bb trumpet or flugel, though, mostly for speed.


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