Between the two options presented, I'd probably go for the Mackie, since it's built for stage use. The Dragonfly looks like it would break after one gig. I'd also avoid the Focusrite 2i2 suggestion as it can probably break much easier than the Mackie, although sonically it would be fantastic.

I'd suggest a USB mixer if possible and just use the Eon as a speaker, since I assume you'd need a mixer of some sort and a separate mixer would put the controls more easily available. Mackie, Yamaha, and Soundcraft all make nice small-format mixers with USB.

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