I appreciate all the help. If someone is using a Presonus USB 1818 and want to share their ASIO settings, I would be happy to try them. I want to make one thing clear, I am not running Studio One and BIAB at the same time. I am running BIAB by itself. I tried scores of buffer settings and could get it to work so I am using MME. I don't know why that is a big deal. When I open Studio One it goes right to ASIO and when I open BIAB it goes to MME, that's it. Again if someone wants to suggest settings I have not tried yet, I would be happy to try them. Like I said earlier I tried 128 up to 1028, what's left to do?