I have checked the routing and everything are correct.
What is different between Realband and Band in a box's Audio settings, because Kontakt 6 works OK in Realband! The same goes for Reaper. It is just BIAB.
The problem keep happening when Loading a song with the saved plugin settings. If I load any song and then changing a MIDI track so to use a Kontakt instrument, it changes it and play it with no problem. The problem occurs when re-opening\Loading the file. The initial spike is the audio CLIPPING and many times ALL audio within BIAB shuts down, so I need to close BIAB and restart it back again.
All of my Audio and video Drivers are up to date.