I do both in the same room setting. It's largely depending on who was I playing with. If there was going to be a drummer or a B3 organist, I would go with the PA system. It would also serve to bring out the stereo effects from my processors. Whereas, if it were in a trio setting with Jazz covers I would use just the amp. And there were times when I was in the mood to hear my amp because the warmth of the room really did a far better job of creating ambiance than my amp simulators could. In those times I would mic the amp.

The best answer I can supply is it would be contigent on the environment, other instruments, and musical genre I am walking into. In any event, I would bring everything to cover my bases and use the best option. I particular like that size room you are speaking of. Because it can be intimate. Yet, if you are asked to drive your sound, a PA will keep the overhead under control while you drill into your axe.

hope that helps!

RickeG