I had mouse-wrist problems for a long time.

I had a selection of mice, including a "penguin", trackballs, tablets and I used a wrist splint. I could also use any of those with either hand, thou my dominant hand was, of course, quicker but painful.

The single best mouse was the penguin (one could also think of another name for it)
https://www.posturite.co.uk/penguin-ambidextrous-vertical-mouse
It has a switch to swap functions to better suit left or right hand.

I had a technical writer friend whose solution was to push the keyboard away, use the mouse dead centra, rather than off to the side, then push the mouse away and pull back the keyboard. That works well if one mostly uses keyboard short-cuts.

Keyboard short-cuts are great once on gets familiar with them, but unfortunately some software just doesn't use them :-(

Jazz relative beginner, starting at a much older age than was helpful.
AVL:MXE Linux; Windows 11
BIAB2025 Audiophile, a bunch of other software.
Kawai MP6, Ui24R, Focusrite Saffire Pro40 and Scarletts
.