From the postings on the Melodyne forum there are issues with several of the major programs like cakewalk and Pro tools and the Melodyne DNA editor.
Don't know about Reaper since I have still not gotten the hang of most of the ways to work with in Reaper. There is a update 1.1? to DNA editor coming out soon and if it were me, I'd wait till there was some positive feed back before jumping on the cutting/bleeding edge of DNA. I think it's a great program when more bugs are worked out , just my 2 cents. Wyndham