Which Scarlett do you have?
I assume it's the SOLO as that's one mic & one guitar.
Depending on the model there may be other options available.
I have an older model Focusrite with line inputs spots on the back...I was able to run external preamps and guitar Fx into those.
For the solo note that the Helix has a balanced out and the SOLO guitar input is also balanced.
You'd get BEST sonic results from the HELIX by using a cable that is balance TRS AND use the "INST" button to select line level, (NOT red), so that the Helix and interface work together nicely.
When not using the Helix, or other line level units, for guitar you should select INST red and turn UP the gain on the Scarlett.
If you were using a DAW like REAPER you could set up the Helix via USB to get the best from it and ensure you have stereo when using stereo FX, as well as having the Scarlett for vocals etc.
I suspect the active DI boxes are of no real use for your current set up as they turn most signals into a line level signal or from a line level depending o the box.


Last edited by rayc; 04/01/22 04:47 PM.
Cheers
rayc
"What's so funny about peace, love & understanding?" - N.Lowe