I have just switched from an analog signal chain (i.e. pedals, amps and microphones to a helix. I also used an audio interface but mine has two inputs. One of the problems I experienced is the daw only recognizing one usb connection at a time. There is an asio driver called asio4all but it is more trouble than it is worth. Made my usb set up very unstable.

Here is a suggested workaround. The Helix has lots of usb inputs and outputs (8). You can record a dry track and wet track in your daw at the same time. You can do this in any daw. As Ray mentioned Reaper is a good budget friendly daw. The DAW plugin from band in a box works excellent in the DAW.

If you break your workflow into two phases. Recording and Mixing. You use the multiple usb inputs of the Helix to record tracks. You can use also the Helix now to reamp if you want to play with a different effects chain or you can use the Helix Native (vst) to adjust your tones in real time.

I prefer my audio interface for mixing as I prefer it running my studio monitors. I do not like the Helix for playback.

I started with the Focusrite Scarlett Solo. It is excellent for playback but it is challenged for input options.

Scott Collingwood
https://soundcloud.com/scottt709
https://soundcloud.com/spiritlevel-ca
https://www.youtube.com/@SpiritLevel-ge3hm/