As a gigging musician, I've played more 3 chord songs than I can count. Plenty of 2 chord songs and more than enough 1 chord songs. (IMO, any 1 chord song is too much – as it is very difficult to improvise a long, interesting melodic solo over one chord.)
As Mario pointed out, MIDI is unlimited.
If I want that piano part to be a clav, synth, guitar or whatever, click, click and it's done. If I want to change sounds every two measures (or whatever) – presto change-o.
If I want that part up or down an octave, no prob.
Wanna add a song specific figure with the same sounding instrument as the rest of the song – play it in.
Using Real Band or exporting your tune as a MIDI file and importing to a sequencer/DAW gives you absolute unlimited editing and customizing capabilities.
Do you want a specific note on top of the chord when BiaB puts it in the middle, click click or drag and drop.
Don't want that drum roll between the A and B section, copy/paste.
Want a different roll there, again copy/paste.
How about a ride bell or cowbell instead of a ride cymbal? Drag/drop.
Longer ending or better intro, your sequencer/DAW/RealBand is your friend.
Need a rhythmic kick, or need to add or subtract instruments to a BiaB hit - easy-peasy.
Real crescendos, diminuendos, accelerandos, or ritardandos instead of the rough ones available in BiaB - couple of clicks and it's done.
This only scratches the surface.
Back On Topic.
Songs need variation and development. A lot of one chord songs do that by changing instruments, adding and subtracting them, adding song-specific figures and develop those figures and so on. This can easily be done with MIDI styles.
EDM songs have changes that happen through them, if you pay attention, you will notice them. Granted, they aren't as obvious as the chord changes in a multi-chord song, but they are there and take a different kind of listening to discover them.
That's where a good MIDI EDM Multi-style comes in. Instead of A and B sections, you have A, B, C, and D. By adding/subtracting the individual instruments in the A-B-C-D parts you can expand that and have the gradual changes that make EDM interesting to the dancers.
Of course, YMMV
Insights and incites by Notes ♫