Some ASIO interfaces have very particular bugs / behaivour with endless variations/combinations of software+hardware.

For example I have a portable ASIO interface... If I change buffers on it's own control panel, BIAB would detect "Change in audio device" and then fall silent. No sound will come out of BIAB. The trick I found was just to enter ASIO setting in BIAB without changing anything and exiting out of it. That way it refreshes the connection and life becomes beautiful again. I was not able to find any other solutions to that glitch. Interface is Apogee One.

The moral of the story is, if you can get your hands on / borrow something comonly used, like Focusrite, that will give you a much clearer picture of the issue.

P.S. I assume you already tried downgrading/upgrading/reinstalling interface drivers & firmware. That can also be an issue. For the interface I described above, newest driver is a nightmare. Stuttering and all that wonderful stuff. I had to downgrade to make it work right.