Thanks everyone for responding. I'm using the 2020 BIAB version on a Windows 11 machine. It definitely doesn't save those preference settings with the saved song, when I reload the song, they are reverted back to the standard location. I opened the program as the administrator as "Audio Track" suggested - same issue. I tried saving the preferences as Jim F suggested, when I tried to open that preference file, the program crashed - I think that's a different problem, but in any case, having to open a separate preference file each time I start up the program wouldn't be much less hassle than just updating the RealTracks Preference.

I guess it's something specific to my setup?