Hi Jim, I have tried reopening the same song, other songs, rebooted, etc. As AT said, the Preferences are universal, so they should be saved across all songs, but in my case, they are not. AT, to answer your question, I have RealDrums and RealTracks in one location, on the external drive. Once I change the preferences to the correct location, everything works, until I close the program and reopen for another session, then I find the preferences have reverted to the C drive and must be changed again.
Very weird, especially since Rustyspoon does not have this problem.