I haven't personally had any negative experiences with mini laptops and running them all day. So long as you keep the typical things in mind for taking good care of your computers and you always take a look at the specs to see if it'll do what you're looking for, no reason why it can't be left running for as long as you like. That's what the fans and such are for, and if you ever find there's a problem with it getting a bit hot cooling mats or always an option too. Just make sure—as I am sure you already know—make sure the vents are clear for proper aeration. A lot of laptops have the vents on the bottom so a bit of elevation is your friend.


Cheers,
Ember