Granted I have a wacky setup but the Video plays a big part of whether I have issues or not. I run multi outs with my card.In RB my screen is set up to display part of the chord sheet, part of the tracks view & part of the comments screen.I found out ,and it's consistent, that if the track view changes screen & the chord sheet change screen at the same time it'll throw the soundcard's outputs out of sync.I was able to solve this by disabling the network card.I've now created a new HW Profile with all the stuff I don't need disabled.
I miss this, HW Profiles, on my Win7x64 lappy.The Win 7 machine seems fine though. A whole lot more horse power.

John
ESI Gigaport HD+
Lenovo Turion II /4 Gig Ram/ Win7x64 be
15.6" Monitor
"The only Band is a Real Band"
www.wintertexaninfo.com/BANDS/JohnnyD.php