Yes, I do it all the time using ASIO Sound Drivers, a DXi synth and that "ASIO Always On" checked.

UNcheck the "Route MIDI Thru" as well, so that you are sure to be playing through the DXi synth and not thru whatever non-DXi synth is highlighted in the window above.

Also a good idea to leave the dropdown set to "Good" or "Better" as "Best" can often hang things up and quite honestly I hear no sonic difference.


--Mac