The Saffire is ASIO only.

Did you go thru Options->MIDI/Audio->Audio Settings and then use the dropdown to select ASIO?

Also note the "Audio Drivers" button just below that dropdown, hit it and there's another window where you must select the Audio ASIO Inputs and Outputs. You have plenty available in that Pro40, but remember that BiaB can only handle one stereo pair input and one output.

Also, with most ASIO drivers, I have found it necessary to check the "ASIO Always On" button with BiaB, but you should experiment with that one to see which way works best.

Good Luck,

--Mac