Could it be:

Buffer overload in your soundcards drivers?

Distortions do to track(s) volume?

Interference caused by some close wireless device like phone, modem?

IRQ sharing problem?

Some programs running in the background like antivirus?

Does it happen in the stand-a-lone version of Amplitude 3?

You said you only hear it in RB so it does not happen in any other audio program like BiaB, YouTube, CD playing?

Have you checked any of the above? Tracing down intermittent problems like this can be extremely frustrating but I’m sure with all the help from this forum the problem will be found.

Whenever I get something stuck in the back of my throat, I dislodge it by drinking a beer.
It's called the Heineken Maneuver.

64 bit Win 10 Pro, the latest BiaB/RB, Roland Octa-Capture audio interface, a ton of software/hardware