..Once I run and install the program within the sancbox, Can I then just run outside the sandbox, or I have to reinstall it again? Seems Ccleaner needs updating again outside of sandbox.
Thanks
Musiclover
Yes CC needs to be running on the main drive to work.
If you run a program installer it will install in the sandbox drive and always run from there. Once you have run a program and know it's safe then you can install it without using sandboxie, same with an exe file you are not sure of, run sandboxed make sure it's what it says it is then run it normally.
If you go to the C:\sandboxie and look it there it is like another drive with Program Files folder etc. If you get any crap just delete the sandbox.
Ideally what GH Herb does is the way to go, but this might be the second best if you just have the one machine.
You can also use
VirtualBox as a sacrificial OS, once installed and setup you make a copy of the virtual machine image, any crap just delete the OS (image) and replace it with a fresh clone copy. You can just transfer safe files thru a usb stick.