Set your Treble and Bass controls at the 12'oclock mark. That is usually the "design point" and should be flat enough for all intents and purposes.

At very low volume levels, which is what I recommend for mixing because the ears don't fatigue as quickly and it is also easier to hear things in a mix at "conversational" levels, it is generally okay to move both Bass and Treble to the 1 o'clock point, which compensates for the Fletcher-Munson curve a bit better at those levels.

Most important aspect of *any* monitors is to get to know them well. Spend a lot of time listening to them at those same levels, using professionally mixed and mastered "reference recordings" of the same basic genre and style in which you intend to mix. Get to know them well and you'll get to know when they don't sound right on your own mixes. When it sounds "right" -- meaning pretty much like your reference recordings do, your mixes will translate well to other systems.


--Mac